Search on: NUCLEAR REPROGRAMMING 
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Descriptor English:   Nuclear Reprogramming 
Descriptor Spanish:   Reprogramación Nuclear 
Descriptor Portuguese:   Reprogramação Nuclear 
Tree Number:   G05.355.680
Definition English:   The process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state. This process can be achieved to a certain extent by NUCLEAR TRANSFER TECHNIQUES, such as fusing somatic cell nuclei with enucleated pluripotent embryonic stem cells or enucleated totipotent oocytes. GENE EXPRESSION PROFILING of the fused hybrid cells is used to determine the degree of reprogramming. Dramatic results of nuclear reprogramming include the generation of cloned mammals, such as Dolly the sheep in 1997. 
See Related English:   Nuclear Transfer Techniques
 
History Note English:   2007 
Allowable Qualifiers English:  
DE drug effects ES ethics
GE genetics IM immunology
PH physiology RE radiation effects
Record Number:   52479 
Unique Identifier:   D053708 

Occurrence in VHL: 		 

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